ExionLC™ Series UHPLC

Analytical HPLC Solutions for LC-MS

Designed for seamless integration with SCIEX mass spectrometers, ExionLC analytical HPLC and UHPLC systems provide the speed, sensitivity, resolution, and reliability that you need for routine or complex LC-MS analysis.

Pick Your Model

ExionLC AC:
An affordable system that can handle a wide range of applications. With both HPLC and UHPLC capabilities the ExionLC AC is a reliable robust solution for routine analysis.

ExionLC AD (shown below):
The system combines near zero carryover, full UHPLC capabilities to provide world-class performance under the most demanding analytical conditions.

ExionLC
Key Features

Wide Range of Flow Rates

0.0001 to 10.0 mL/min

HPLC/ UHPLC Performance

9,500 to 18,850 PSI

Ultralow Carryover

Innovative flow through design, ability to choose multiple rinse solutions

High Throughput Capability

Up to 768 samples with 384 well MTP (expandable to 12 plates/trays with rack changer option)

Flexible Column Oven Choices

Choice of compact two-column oven, or six-column.

Optional Accessories

Multiplate autosampler (AD only), rack changer, and optical detectors

LC Solutions Tailored to Meet Your Needs

Your lab has unique analytical requirements and our goal is to provide LC-MS solutions tailored to meet your needs. The ExionLC™ Series of robust and reliable HPLC/UHPLC systems offers a wide range of performance and flexibility.

The Power of UHPLC/HPLC Performance

Backed by over 40 years of trusted LC-MS innovation and service, the ExionLC provides you with the versatility, reproducibility and robustness to tackle the toughest applications, from method development to routine analysis, 24/7.

ExionLC AD

Quantitate with Confidence

ExionLC AD combines accurate injection volumes with near zero carryover to make quantitation a breeze.

Unrivaled Reproducibility

Flow rate precision < 0.06% and accuracy of less than 2% gives you the analytical accuracy and precision you need day in and day out.

No Fuss Upgrades

Expand your capabilities with a wide range of options that allow you to simplify method development, automated sample prep or increase throughput.

ExionLC AC

More Performance, Less Cost

The ExionLC AC delivers with its affordable price and HPLC /UHPLC separation capabilities.

Better Results, Faster

Reproducible retention times combined with sensitive, accurate quantitation gives you results you can trust.

Ultimate Flexibility

ExionLC can support multiple components, and configurations to meet the changing demands of your laboratory.

Key Features ExionLC AD ExionLC AC
UHPLC/ HPLC Performance 18,500 PSI (1300 bar) 9,500 PSI (660 bar)
Ultralow Carryover 0.0015% maximum < 0.005%
Cooled Autosampler Direct cooling, 4 to 40°C
(under specified conditions)
Direct cooling, 4 to 40°C
(under specified conditions)
Temperature Controlled Column Oven Room Temp. +5° C to 150°C, 2 column capacity
(AC column oven also compatible)
Room Temp. -10° C to 85°C, 6 column capacity
(AD column oven also compatible)
Wide pH Range 1-9 (standard)
1-14 (optional)
1-14

Pick Your Application

Pharma and Biopharma

Make confident decisions faster, resulting in more efficacious, safer therapeutics.

Food and Beverage Testing

Solutions to test and protect our global food and beverage supply.

Forensics Testing

Complete forensic drug testing solutions to help you uphold result integrity.

Life Science Research

Accelerate the pace of your research to identify key genes, proteins, lipids and metabolites.

Customize Your ExionLC

Modular components allow you to update your system to keep pace with changing requirements. Add a column switching valve, two additional pumps and do on-line SPE. Add a PAL autosampler for automatic sample dilution or on-line microSPE.

Solvent Selector Valve

Allows you to select between two solvents per channel from up to 3 different pumps.

UV Detector

Time programmable wavelength switching allows detection sensitivity and selectivity.

Rack Changer

Up to 12 additional cooled sample trays or vial racks to the AC or AD system.

PDA Detector

Excellent option for ID, quantitation, and purity analyses at trace levels.

Multiplate Autosampler

Expands capacity with 324 x 1.5 mL vials, or 6 microtiter plates in 96 or 384 formats.

PAL Autosampler

Increase productivity by adding a PAL RSI or PAL RTC Autosampler.

Resources

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Système HPLC Guide d'aménagement sur site

ExionLC_overview_2018_121718

Exion LC AD Multiplate Autosampler

ExionLC™ Degasser Operator Guide

Dégazeur ExionLC™ Guide de l’opérateur

Détecteur UV ExionLC™ Guide de l’opérateur

Détecteur PDA ExionLC™ Guide de l’opérateur

ExionLC™ UV Detector Operator Guide

ExionLC Rack Changer

Rack Changer ExionLC Guide de l’opérateur

ExionLC™ PDA Detector Operator Guide

Simultaneous Determination of 7 Kinds of Local Anesthetics in Cosmetics by High Performance Liquid Chromatography-Mass Spectrometry (ZH)

High-sensitivity detection of forensic drug panel in human whole blood (ZH)

Determination of 20 Steroid Hormones in Human Serum Samples by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Single-Injection Screening of 664 Forensic Toxicology Compounds Using an Innovative Benchtop High Resolution Mass Spectrometer

Ultra-Sensitive Forensic Analysis Workflow of Cocaine andIts Metabolites in Hair Samples Using LC-MS/MS

Intelligently Designed SWATH® Acquisition for Novel Psychoactive Substances (NPS) Detection in Whole Blood

Quickly identification of phase II metabolites in plasma after oral Compound Traditional Chinese Medicine by SCIEX TripleTOF system software

Targeted and Untargeted Detection of Fentanyl Analogs and Their Metabolites in Hair by Means of UHPLC-QTOF-HRMS

High-sensitivity detection of forensic drug panel in human whole blood

ExionLC Rack Changer

ExionLC AC Column oven-120 and AC Column oven-240

ExionLC Degasser

ExionLC AC Autosampler

ExionLC PDA Detector

ExionLC 100

ExionLC Controller

ExionLC AC Pump, AD Pump, and HPLC Pump

The Application Solution for Determination of 19 Organic Acids by LC-MS-MS Method

Determination of Nitrofuran Metabolites in Animal-derived Food

Quantification of Dopamine, Epinephrine, Norepinephrine in Human Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

SCIEX LC-MS-MS Application Technology on Origin Identification of Dairy Products based on Alpha-lactalbumin and Beta-lactoglobulin

Determination of Aflatoxins B and G in Grain

LC-MS-MS Method for Determination of 523 Pesticide Residues in Traditional Chinese Medicine

The Solution of Analysis 13 Nitrosamines in Drinking Water by LC-MS-MS

Determination of Six Antipsychotic Drugs in Serum by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Determination of beta-Amyloid Peptide in Human Cerebrospinal Fluid

Targeted Analysis of Eicosanoid in Plasma by LC-MS-MS

Quantification of 74 Prohibited Hormones in Cosmetics Using LC-MS-MS System

Determination of Liposoluble Vitamins in Micro Blood Samples by SCIEX Liquid Chromatography Tandem Mass Spectrometry

Determination of Sulfonamide Residues in Chicken

Determination of Beta-agonist Residues in Meat

Application of the QTRAP system in the screening of extractable substance of packaging materials

Application in Screening of Packaging Material Extracts Based on X500R QTOF High Resolution Mass Spectrometry

Metabolomic Approach for the Authentication of Berry Fruit Juice by TripleTOF 5600+

Determination of roxarsone in animal feeds using solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry

A Rapid Screening and Quantitative LC-MS-MS Method of 189 Veterinary Drug Residues in Animal Food by High Resolution Mass Spectrometry X500R

The Application of TripleTOF 5600 System for Identification of Chemical Components in Polygonum Cuspidatum

处理前后的饮用水筛查的两种非靶向流程

The Application of Analysis 13 Haloamides in Drinking Water by LC-MS-MS

Identification of Carbamate Pesticide Metabolites in Soil with LightSight Software Combined with QTRAP System

The Application Solution for Determination of Fluconazole and other 8 Kinds of Components in Cosmetics by LC-MS-MS Method

Composition Identification of Leachable from Polypropylene Infusion Bottle by X500R High Resolution Mass Spectrometry

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Analysis of Six Organotin Compounds in Food package Material by LC-MS-MS

A Rapid Screening and Quantification Method of Forbidden and Restricted Pesticides in Traditional Chinese Medicine by LC-MS-MS

Simultaneous Determination of 14 Paralytic Shellfish Toxins in Seafood using LC-MS-MS

Determination of Nitrofuran Metabolites in Animal-derived Food

Detection of 8 Antioxidant Residues in Food Package by Triple Quad 4500

Analysis 106 Compounds in Cell Supernatant by Using LC-MS-MS

Determination Trace Residues of Whey Protein in Lactose by LC-MS-MS

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Simultaneous quantitative analysis of metronidazole and chloramphenicol in chicken by SCIEX LC MS-MS

Rapid Determination of 36 Anti-infective Drugs in Cosmetics by LC-MS-MS

Identification and Quantitation of Poisonous Alkaloids in Blood by SCIEX QTRAP

A Rapid Screening and Quantitative LC-MS/MS Method of 11 Lipophilic Marine Toxins in Seafood Using SCIEX Triple Quad™ 4500 LC-MS/MS system

Determination of Protein Sequence Mutation and Complex Post Translation Modification on the X500B QTOF System

Rapid Characterization of the Cow Milk and Human Breast Milk Lipidome using High Resolution Mass Spectrometry X500R System

A Rapid Screening and Quantitative LC-MS-MS Method of 14 Sulfonylurea Herbicides Residues in Water by Direct Injection using Triple Quad 3500

Establish a rapid and efficient method for the determination of nitrosamines in cosmetics and personal care products

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Simultaneous determination of 16 sunscreens in Sunblock Cosmetics by Triple Quad 3500

A New Method for Screening, Identification and Quantitation of Fentanyl and its Derivatives by SWATH of X500R

Determination of Malachite Green and Crystal Violet Residues in Fish

Determination of 74 Pesticides and metabolites in Soil By LC-MS-MS

Determination of 23 Phthalate Esters in Drinking Water By LC-MS-MS

Determination of Quinolone Residues in Animal-derived Food

Determination of Genotoxic Impurities Methyl Methanesulfonate and Ethyl Methanesulfonate on SCIEX Triple QuadTM 4500 system

Determination of 23 Phthalate Esters in Cosmetics By LC-MS-MS

A Rapid Screening and Quantitative LC-MS/MS Method of 247 PPCPs and Pesticide Residues in Water by Large Volume Injection

Determination of Malachite Green and Crystal Violet Residues in Fish

CESI-MS/MS和LC-MS/MS技术对生脉注射液成分的分析

Determination of 13 Bile Acids in Serum by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Identification of Extractable and Leachable in Single Use Packaging of Drug on the X500 QTOF System

Rapid Determination of 8 Macrolides Antibiotics in Cosmetics

The solution for amantadine, rimantadine and ribavirin residues in animal-derived foods by LC-MS /MS

Determination of Aflatoxins B&G in Grain

LC-MS-MS Method for Rapid Determination of 30 Forbidden Pesticides In Traditional Chinese Medicine

Determination of Caspofungin Posaconazole Voriconazole N-Oxide and Voriconazole in Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Rapid and Sensitive Analysis of Drugs of Abuse by SCIEX Triple Quad 3500 LCMS System

High Resolution Mass Spectrometry X500R QTOF System on The Routine Monitoring of Cosmetics Illegal Drug

Detection of 13 Haloamides in Drinking Water by Triple Quad TM 5500

Determination of Quinolone Residues in Animal-derived Food

Forensic Authentication of Hemp-Derived Products Using Mass Spectrometry

The Application Solution for Determination of Minoxidil and Other 6 Kinds of Components in Cosmetics by LC-MS-MS Method

Confirmation of Contaminants in Water Using SCIEX Triple Quad 5500plus QTRAP Ready

Identification and Quantitation of Fentanyl and Analogues in One Injection by SCIEX QTRAP

The Solution of Methamphetamine Detection

LC-MS-MS Method for Rapid Determination of Volatile Aldehydes in Cells

Improving throughput using the ekspert™ ultraLC system

Emerging food_QTRAP 6500+_PFFA food and food packaging_SCIEX_RUO-MKT-02-2755-A.docx

Forensic identification and quantification workflows delivered on QTOF and SCIEX OS software

LC-MS/MS Analysis of Emerging Food Contaminants

Profiling of Hop-Derived Bitter Compounds in Beer Using LC-MS/MS

Unknown Screening_X500R QTOF SCIEX OS_food_SCIEX_RUO-MKT-02-3761-A.docx

Identification and quantitation_X500R QTOF SCIEX OS_food_SCIEX_RUO-MKT-02-3760-A.docx

Fast and simultaneous analysis of ethanol metabolites and barbiturates using the QTRAP® 4500 LC-MS/MS system

No Slide Title

Identification and quantitation_X500R QTOF SCIEX OS_food_SCIEX_RUO-MKT-02-3760-A.docx

mAb Oxidation Analysis using X500B and Peptide Mapping

RUO-MKT-02-5388-A Rapid and Sensitive Analysis of Antibiotics in Children’s Urine Using the X500R QTOF System

Fast Screening Method for 86 Forensic Analytes in Human Urine QTRAP 4500

Microsoft Word - A Robust and Generic Method for Quantification of Monoclonal Antibody Therapeutics in Biological Matrices_FINA

Intact Analysis of Antibody Drug Conjugates

Increased Throughput for ADME Studies Using the SCIEX ExionLC� AD UHPLC System

HRAMS Assay for Trastuzumab

Amlodapine Bioanalysis v10.docx

Quantitative Analysis of Fentanyl and Analogues in Whole Blood - QTRAP 4500 System

Streamlined Unknown Screening for Postmortem Analysis Using SWATH Acquisition

LC-MS/MS Method for the Quantification of Budesonide in Human Plasma

Rapid Identification and Quantification of Novel Psychoactive Substances in Human Whole Blood Using SWATH® Acquisition

Isotopic Resolution of Chromatographically Separated IdeS Subunits Using X500B QTOF System

Routine Workflow for Comparability Assessment of Protein Biopharmaceuticals

Potency Analysis in Hemp and Cannabis Products using a Single-Dilution Combined LC-UV-MS/MS Approach

Metabolite Identification of Payload Species of Antibody Drug Conjugates with Noncleavable Linkers

Characterization of 2-AB Labelled Released N-linked Glycans Using the X500B QTOF System

Analysis of Streptomycin and its Metabolite in Milk Using the SCIEX Triple Quad 3500 System

Cannabis for Per Se Law Testing in Whole Blood using theSCIEX Triple Quad QTRAP 4500 LC-MS/MS System

Identification and quantitation_X500R QTOF SCIEX OS_food_SCIEX_RUO-MKT-02-3760-A.docx

Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine using the QTRAP/Triple Quad 4500 LC-MS/MS System

Emerging food_QTRAP 6500+_sodium fluoroacetate_SCIEX_RUO-MKT-02-2756-A.docx

Determination 29 β-Agonists in Animal Derived Food by LC-MSMS Method (ZH)

To Develop Quantitative Analysis Method of Intact Insulin Lispro By SCIEX Triple Quad 7500 System (ZH)

Separation of Bile Acid Isomers with Differential Mobility Spectrometry

Comparative peptide mapping between two manufacturers of Trastuzumab using the X500B QTOF System

Analysis of the Massachusetts Cannabis Pesticides List Using the SCIEX QTRAP® 6500+ System

Rapid Analysis of Genotoxic Nitrosamines

Isotopically Resolved Subunit Analysis for Tracking Protein Therapeutic Stress Studies

Authentication and Geographical Origin Analysis of Plant-Derived Edible Oil Using the SCIEX X500R QTOF System

Two Nontargeted Screening Approaches for Examination of Drinking Water During Treatment

Confirmation of Contaminants in Water Using SCIEX Triple Quad™ 5500+ LC-MS/MS System − QTRAP® Ready and SCIEX OS-Q Software

Microsoft Word - RUO-MKT-02-7052-A - Technote - High Throughput Platform for Confident Identification and Quantitation of Organic Explosives.docx

Elevating the Forensic Laboratory Performance

Efficiently Designed Workflows Provide Accurate Results in Forensic Analysis of THC-COOH in Hair

Rapid, Sensitive, Quantitation method for Chloramphenicol in Meat using SCIEX Triple Quad 3500 LC-MS/MS System

Quantitative and Qualitative Analysis of Cell Culture Medium Using SWATH® Acquisition

Achieving California Pesticide Regulations in Cannabis Using Optimized APCI and ESI Techniques

Forensic Authentication of Hemp-Derived Products Using a Dual Mass Spectrometry-UV Detection Approach

Detection of Growth Hormone-Releasing Peptides in Dried Blood Spots: Workflow for Anti-Doping Analysis

Detection of Fentanyl Analogs and Novel Synthetic Opioids in Hair

A Rapid And Sensitive Reverse Phase Method for Analysis of HaloAcetic Acids in Drinking Water

Next Generation Quality Control in Pharma Applications

Evaluation of Critical Attributes on Different Lots of Adalimumab Using BPV Flex Software 1.0.1

The Quantitative Power of SCIEX Triple Quad and the QTRAP® 6500+ LC- MS/MS System for the Bioanalysis of Biotherapeutics

Increased Throughput for the Characterization of Bispecific Antibodies on Subunit Level using SelexION® Differential Mobility Separation Technology

A New Level of Compliant-Ready Intact Biotherapeutic Protein Quantitation using Reconstructed Masses

Characterization of adeno-associated virus capsid proteins with peptide mapping

Highly sensitive LC-MS/MS workflow for targeted quantification of host cell proteins

Extractables and Leachables Analysis from Laboratory Tubing

A Comprehensive and Rapid Method for Quantifying Nitrosamine Compounds - Using the SCIEX QTRAP® 6500+ LC-MS/MS System

Rapid and Sensitive Detection of 8 Organic Explosives in Soil

Rapid Identification and Quantification of Performance-Enhancing Stimulants in Human Urine Using High-Resolution Mass Spectrometry

Chemovar Typing of Cannabis Strains with MarkerView and SCIEX X500R QTOF System

Highly Sensitive LC-MS/MS Method for Quantification of Barnidipine in Human Plasma

Highly Selective and Sensitive Method for Quantification of Nitrosamines in Valsartan Drug Substance

Highly Selective and Sensitive Method for Quantification of Nitrosamines in Valsartan Drug Substance

Quantitative Amino Acid Analysis in Cell Culture Media Using SWATH Acquisition

Compliant attribute monitoring for biopharmaceutical product quality attributes employing intact mass analysis

Comparing microflow vs analytical flow high-performance liquid chromatography for the analysis of pesticides

Confirmación de contaminantes en el agua utilizando el sistema SCIEX Triple Quad™ 5500+ LC-MS/MS - QTRAP® Ready y el software SCIEX OS-Q

High-Sensitivity Detection of Forensic Drug Panel in Human Whole Blood

Rapid DUID Screening of 17 Drugs of Abuse in Plasma and Saliva

Solución Cuantitativa LC-MS para el Análisis Dirigido de Medios de Cultivo Celular

Detección de Impurezas de Anticuerpos Intactos en SCIEX X500B

Análisis de Potencia en Productos de Cáñamo y Cannabis Utilizando un Enfoque Combinado de Dilución única LC-UV-MS / MS

Multi-panel detection of drugs and drug metabolites in hair samples using a comprehensive extraction method

Comprehensive Analysis of Low Abundant Mannose Glycopeptides in Peptide Mapping of Adalimumab

Método LC-MS/MS de cambio de polaridad cuantitativa para pesticidas PPCP en muestras de agua ambiental

Comprehensive Characterization of a site-specific antibody-drug conjugate (ADC) by subunit and peptide mapping analysis

Rapid, sensitive analysis of sphingolipid variant profiles with simplified sample extraction

Elucidation and tracking of charge variants in antibodies: combining ease-of-use with gain in information